“Cre” ating new tools for smooth muscle analysis
BJ O'Brien, KA Martin, S Offermanns - … , thrombosis, and vascular …, 2023 - Am Heart Assoc
BJ O'Brien, KA Martin, S Offermanns
Arteriosclerosis, thrombosis, and vascular biology, 2023•Am Heart AssocSmooth muscle cells (SMCs) form the muscular layer of blood vessels and the viscera in the
gastrointestinal, urinary, and reproductive systems and airways. These quiescent
differentiated myocytes retain a remarkable plasticity that allows for vascular remodeling and
repair. In response to injury, inflammation, or hypercholesterolemia, vascular SMCs can
dedifferentiate and proliferate as a protective response but when unchecked, can drive
intimal hyperplasia, atherosclerosis, and other pathologies. 1, 2
gastrointestinal, urinary, and reproductive systems and airways. These quiescent
differentiated myocytes retain a remarkable plasticity that allows for vascular remodeling and
repair. In response to injury, inflammation, or hypercholesterolemia, vascular SMCs can
dedifferentiate and proliferate as a protective response but when unchecked, can drive
intimal hyperplasia, atherosclerosis, and other pathologies. 1, 2
Smooth muscle cells (SMCs) form the muscular layer of blood vessels and the viscera in the gastrointestinal, urinary, and reproductive systems and airways. These quiescent differentiated myocytes retain a remarkable plasticity that allows for vascular remodeling and repair. In response to injury, inflammation, or hypercholesterolemia, vascular SMCs can dedifferentiate and proliferate as a protective response but when unchecked, can drive intimal hyperplasia, atherosclerosis, and other pathologies. 1, 2
Am Heart Assoc
